王彦英 （1981年3月）         

博士          

E-mail：wangyy@bnu.edu.cn

 ■2011年于北京协和医学院基础医学研究所获博士学位，2012年-2022年在中国科学院生物物理研究所先后任助理研究员、副研究员。2022年加入北京师范大学生命科学学院。长期致力于肿瘤干细胞自我更新调控和肿瘤发生的分子机制研究，相关研究成果发表在Cell Stem Cell、Nature Cell Biology、Nature Immunology、Journal of Hepatology、Molecular Cancer、The Journal of Clinical Investigation、Nature Structural and Molecular Biology、Nature Communications、EMBO Journal等期刊上，并申请多项国家发明专利。获得国家重点研发计划、国家自然科学基金委、和北京市自然科学基金面上项目等的资助。2016年入选中国科学院青年创新促进会会员、2020年被评为中国科学院青年创新促进会优秀会员，获得人才项目资助。2018年获得北京市科学技术奖一等奖。2020年获得了国家自然基金委优秀青年基金项目资助。

 ■肿瘤干细胞与肿瘤微环境。探究肝癌肿瘤微环境中的免疫细胞或细胞因子对肿瘤干细胞自我更新的调控。

 ■肿瘤干细胞不对称分裂的分子机制。

 ■肿瘤转移的新机制。

1. Wang Y*, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Yang G, Dominissini D, He L, Tian Y*, Yi C*, and Fan Z*. N1-methyladenosinemethylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021 Nov 2;12(1):6314.

2. Gu Y#, Wang Y#*, He L#, Zhang J#, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, and Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer 2021,20, 132.

3. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Chen R*, Tian Y*, and Fan Z*. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 38(17):e101110.

4. Wu J#, Zhu P#, Lu T#, Du Y#, Wang Y#, He L, Ye B, Liu B, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, and Fan Z*. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 2019;70(5):918-929.

5. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R*, Tian Y*, and Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. J Hepatol. 2018;69:861-872.

6. Zhu P; Zhu X; Wu J; He L; Lu T; Wang, Y; Liu B; Ye B; Sun L; Fan D; Wang J; Yang L; Qin X; Du Y; Li C; He L; Ren W; Wu X; Tian Y*; Fan Z*. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019, 20(2):183-194.

7. Zhu P#, Wu J#, Wang Y#, Zhu X#, Lu T#, Liu B, He L, Ye B, Liu B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Y Du, li C, He L, Ren W, Wu X, Tian Y*, and Fan Z*. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018; 20: 1134-1144.

8. Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, and Fan Z*. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signaling. Nat Commun. 2015;6:7122.

9. Ye B; Liu B; Yang L; Zhu X; Zhang D; Wu W; Zhu P; Wang Y; Wang S; Xia P; Du, Y; Meng S; Huang G; Wu J; Chen R; Tian Y*; Fan Z*. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018, 37(8).

10. Ye B; Liu B;  Hao L; Zhu X; Yang L; Wang S; Xia P; Du Y; Meng S; Huang G; Qin X; Wang Y; Yan X; Li C; Hao J; Zhu P; He L; Tian Y*; Fan Z*. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018, 9(1).

11. Zhu P#, Wang Y#, Huang G, Ye B, Liu B, Wu J, Y Du, He L, and Fan Z*. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016; 23 (7):631-639.

12. Zhu P#, Wang Y#, Wu J, Huang G, Liu B, Ye B, Y Du, G Gao, Y Tian, He L, and Fan Z*. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608.

13. Li C; Du Y; Yang Z; He L; Wang Y; Hao L; Ding M; Yan R; Wang J; Fan Z*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 76(5):1273-1283.

14. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R*, and Fan Z*. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015（16）；413-425.

15. Zhu P#, Wang Y#, He L#, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, and Fan Z*. Zic2 Drives Self-renewal of Human Liver Cancer Stem Cells. J Clin Invest. 2015;125(10):3795–3808.

16. Song G, Liu Y, Wang Y, Ren G, Guo S, Ren J, Zhang L, and Li Z. Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib. Clinica Chimica Acta. 2015, 440:44-48.

17. Wang Y, Song G, Qiu L, Qin X, Liu H, Li F, Wang X, Guo S, Zhang Y, and Li Z*. Elevated Serum Levels of Circulating Immunoinflammation-Related Protein Complexes Are Associated with Cancer. J Proteome Res. 2014, 13(2): 710-719.

18. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, and Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 211: 2439-2454.

19. Yang X#, Xu M#, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, and Fan Z*. Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2014, 70(4): 1094-1103.

20. Chen G, Wang Y, Qin X, Li H, Guo Y, Wang Y, Liu H, Wang X, Song G, Li F, Guo S, Qiu L, and Li Z*. Change in IgG1 Fc N-linked glycosylation in human lung cancer: age- and sex-related diagnostic potential.  Electrophoresis. 2013, 34: 2407-2416.

21. Chen G, Zhang L, Wang Y, Guo Y, Liu H, and Li Z*. Letter to the editor. Probing gender-specific change in IgG1 Fc-galactosylation in non-small cell lung cancer patients treated with epidermal growth factor receptor inhibitor. Rapid Commun Mass Spectrom. 2013, 27, 1168-1172.

22. Chen G, Wang Y, Qiu L, Qin X, Liu H, Wang X, Wang Y, Song G, Li F, Guo Y, Li F, Guo S, and Li Z*.  Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer. J Proteomic. 2012, 75(10), 2824-2834.

23. Guo Y, Wang X, Qiu L, Qin X, Liu H, Wang Y, Li F, Chen G, Song G, Guo S, and Li Z*. Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry. Clin Chim Acta. 2012, 414, 135-141.

24. Li J, Zhang Z, Wang D, Wang Y, Li Y, and Wu G*. TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Sig Transd Res. 2009, 29(5): 280-285.

25. Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G*. TGF-β1/Smad7 signal pathway stimulates renal tubuloinsterstitial fibrosis induced by AAⅠ. J Recept Sig Transd Res. 2008, 28: 4, 413-428.