The Integrated Microbial Genomes and Microbiomes (IMG/M) system serves as a community resource for comparative analysis and annotation of all publicly available genomes from three domains of life, in a uniquely integrated context. IMG/M provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence, in the context of reference isolate genomes included from the IMG/M system. IMG Expert Review (IMG/ER) provides support to individual scientists or groups of scientists for functional annotation and curation of microbial genomes of interest, usually prior to their release to Genbank. Additionally, IMG with Microbiome Samples Expert Review (IMG/M-ER), and IMG for the Human Microbiome Project (IMG-HMP).