Expert Opinion on Pharmacotherapy, 2012
View PDFchevron_rightImportance of Clinical and Morphological Correlations in Diagnosing Langerhans Cell HistiocytosisOmayma BakheetMed & Health, 2018
Langerhans cell histiocytosis (LCH) is a clonal histiocytic disorder. The variable clinical manifestations from isolated bone lesion to multisystem disease can cause difficulties and delay in diagnosis. We report a 2 years and 8 months-old girl who presented with a 2 weeks history of persistent fever and weight loss associated with progressive abdominal distension. Physical examination revealed pallor, bilateral proptosis, seaborrheic dermatitis over the scalp and hepatosplenomegaly. Skull X-ray demonstrated multiple lytic lesions at the base and the skull vault. Bone marrow morphology showed numerous abnormal Langerhans cells (LCs) and foamy macrophages. The trephine immunohistochemistry (IHC) stains for CD1a, S-100 and CD68 were inconclusive. The diagnosis of multisystem Langerhans cell histiocytosis (MS-LCH) in this patient was based on the clinical presentation, radiological and morphological analysis. She subsequently received chemotherapy and currently she is on maintenance therapy with a good clinical response. LCH is a rare disease and although the IHC was inconclusive, the correlation of clinical, radiological and morphological data are essential for the diagnosis. Keywords: immunohistochemistry, Langerhans cell histiocytosis, pathology
View PDFchevron_rightLangerhans' cell histiocytosis - Case reportHamed ZartabMedical Journal Armed Forces India, 2005
View PDFchevron_rightLangerhans cell histiocytosisPlauto Christopher Aranha WatanabeView PDFchevron_rightLangerhans Cell Histiocytosis: Clinical, Histopathological and Radiological Case Series Study: An Institutional ExperienceAdel El-Badrawy2020
Background: Langerhans cells histiocytosis (LCH) is a rare disease characterized by the uncontrolled proliferation of Langerhans cells (LCs). This study aimed to explore the clinicepidemiological and pathological data of that disease in our population. Methods: Sixteen patients were referred to the Dermatology and the Clinical Oncology & Nuclear Medicine Departments of our university during the 6 years from 2007 to 2012. Records data were retrospectively analyzed. Pathologic specimens and radiologic films were reassessed by consultants. Case Study El-Gayyar et al.; AORJ, 3(1): 6-19, 2020; Article no.AORJ.54099 7 Results: Pediatric age and male sex predominated. The multifocal uni system (MUS) was the commonest presentation (50% of cases) while the multifocal multisystem (MMS) was found in 37.5% of cases including a case of Letterer-Siwe disease. Microscopic examination revealed dense infiltrate mainly of LCs with characteristic features and positive immunostaining for S100, CD1a and...
View PDFchevron_rightLangerhans cell histiocytosis: a 16-year experienceMARCOS ROCHA VIANAJornal de Pediatria, 2007
View PDFchevron_rightLangerhans Cell Histiocytosis-Clinical and Research UpdateNicola Annels4
View PDFchevron_rightLangerhans Cell Histiocytosis: A Case ReportRavi AmbeyLangerhans cell histiocytosis (LCH) is a rare proliferative disorder in which pathological LC accumulate in a variety of organs. Historically the nomenclature regarding LCH has been confusing because the disease had been subcategorized simply based on different clinical manifestations. Herein, we report a child with classic fi nding of disseminated LCH, categorize and stratify on current recommendations of histiocyte society and discuss its treatment and prognosis.
View PDFchevron_rightImaging of multisystem Langerhans cell histiocytosis in an adultGregory DowneyEuropean Journal of Radiology Extra, 2007
View PDFchevron_rightAdult case of Langerhans cell histiocytosisRyoji TsuboiThe Journal of dermatology, 2007
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