The American Journal of Obstetrics & Gynecology, "The Gray Journal", covers the full spectrum of Obstetrics and Gynecology. The aim of the Journal is to publish original research (clinical and translational), reviews, opinions, video clips, podcasts and interviews that will have an impact on the understanding of health and disease and that has the potential to change the practice of women's health care. An important focus is the diagnosis, treatment, prediction and prevention of obstetrical and gynecological disorders. The Journal also publishes work on the biology of reproduction, and content which provides insight into the physiology and mechanisms of obstetrical and gynecological diseases.

The American Journal of Obstetrics & Gynecology has two companion titles:

Manuscripts with a focus on maternal-fetal medicine or high-risk pregnancy can be submitted to AJOG MFM,

Manuscripts with a focus on regional reports and cross-border healthcare delivery can be submitted to the open access AJOG Global Reports.