陈思锋 教授

一、简介

姓名：陈思锋

职称：复旦大学特聘教授、国家二级教授、博导

地址：上海市徐汇区东安路130号7号楼214室

电话：021-54237623， 15900577521

E-MAIL: chen1216@fudan.edu.cn

出生日期：1963年12月16日

二、教育经历

工商管理硕士（医药卫生）2005-2006 美国阿拉巴马大学伯明翰分校

医学硕士 1985-1988 第二军医大学病理生理学教研室

医学学士 1980-1985 第二军医大学海军医学系

三、工作经历

教授→复旦大学特聘教授 2006-今复旦大学生理与病理生理学系

系主任 2013-2019.3 复旦大学上海医学院生理与病理生理系

主任 2008-2013 复旦大学肾脏与高血压研究中心

系副主任（主持工作） 2008-2013 复旦大学上海医学院生理与病理生理系

助理教授 2003-2007美国伯明翰阿巴拉马州大学医学院内科学系

助理教授级研究员 2001-2003美国佛罗里达大学医学院内科学系

博士后 1998-2001美国佛罗里达大学医学院内科学系

德国洪堡奖学金 1997-1998德国马格德堡大学外科学

执行主任 1995-1997第二军医大学病理生理学教研室

副教授 1992-1997第二军医大学病理生理学教研室

讲师 1988-1992第二军医大学病理生理学教研室

四、研究方向

1. 干细胞转化医学

2. 血管内膜疾病的发生机制

3. 糖尿病及其并发症的免疫机制和免疫治疗

4. 急性肺损伤

五、荣誉与获奖

2016 上海市教委：上海市本科生全英语示范课程Pathophysiology

2016 上海市教委：上海市留学生英语示范课程Pathophysiology

2006 波兰国家科技进步奖（不分名次），波兰国家科技与教育部：国际合作研究血红素氧化酶-1在疾病中的作用。

1997 国家科技进步奖终审答辩(第一完成人): 急性肺损伤的发病机制

1997 德国洪堡奖学金获得者（不分名次）

1997 国际癌症联盟技术转移奖（不分名次）。

1995 军队科技进步二等奖(第一完成人)：血小版活性因子和磷脂酶A2在急性肺损伤中的作用及机制

1995 军队三等功

1994 军队科技进步三等奖(第一完成人)：白细胞-内皮细胞粘附对肺微血管内皮单层通透性的调节研究

1992 军队科技进步二等奖(第五完成人)：急性肺损伤发生机理的实验研究

1991 军队科技进步三等奖(第三完成人)：急性胰腺炎狗肺表面活性物质系统的损伤及机制研究

1990 军队科技进步三等奖(第一完成人)：磷脂酶A2对灌流肺的损伤作用及机制探讨

1989 军队科技进步三等奖(第二完成人)：狗急性胰腺炎所致肺损伤研究

1989 军队科技进步三等奖(第四完成人)：犬急性出血性胰腺炎时II型肺泡上皮细胞板层体体视学

六、国内外学术团体任职（目前在任期内的）

1. 中国生理协会副理事长

2. 中国病理生理协会常务理事

3. 中国微循环协会常务理事

4. 中国生理学会继续教育专委会主任委员

5. 中国生理协会循环专业委员会副主任委员

6. 中国病理生理协会微循环专业委员会副主任委员

7. 上海生理科学会理事长

8. 上海病理生理协会副理事长

9. 中国病理生理协会动脉粥样硬化专业委员会、循环专业委员会、国际心脏协会中国分会等协会的理事

七、国家级基金和人才项目评审

1.国家自然科学基金通讯评审：杰出青年基金、优秀青年基金、重点项目、国际联合项目、地区重点项目、港澳合作项目、面上项目、青年项目

2. 国家自然科学基金会议评审：优秀青年基金、重点项目、国际联合项目、地区重点项目、港澳合作项目、面上项目、青年项目

3. 科技部通讯评审：973项目、青年拔尖人才

4. 科技部通讯会议评审：国家重点研发计划

5.教育部通讯评审：长江讲座教授、长江特聘教授、青年长江

6.中组部通讯评审：青年

八、校内学术机构任职（复旦大学）

复旦大学基础医学院学术委员会委员

复旦大学基础医学院聘任委员会委员

九、主持的国家级科研项目（仅作为paricipant的美国NIH项目、国内非负责人的项目和省部级以下项目从略）：

1. 国家重点研发计划项目（重大慢性非传染性疾病防控研究）: 2016/9-2020/12,1型糖尿病的遗传与免疫发病机制和相关(注：干细胞)防控技术研究，2016YFC1305100，567万元，在研，牵头。

2. 国家自然科学基金重大研究计划项目：2016.01-2018.12,细胞自噬在来源于诱导性多能干细胞的外泌体对血管内膜增生性疾病防治中的作用，91539120，115万元，结题，主持。

3. 国家自然科学基金重点国际（地区）合作与交流项目：2013/01-2017/12, VCAM-1/VLA-4介导的iPS与血管内皮细胞相互作用对iPS防治血管性疾病作用的影响及其机制，81220108002，290万元，结题，主持。

4. 国家自然科学基金重点项目：2009/01-2012/12, 内皮细胞内质网应激在移植肾血管排异反应中的作用, 30830050，185万，结题，主持。

5. 科技部973课题：2009/01-2012/12,新方法（注：干细胞）和新技术（注：基因治疗）在脑卒中研究和治疗中的作用，2009CB521907，270万,结题，主持。

6. 国家自然基金面上项目:2008.1-2010.12，课题编号：30771003，，用带白介素-10的I和II型腺相关病毒共转染移植肾防治慢性肾移植排异反应及其免疫机制

7. NIH/NIDDK 1R21DK071023-01 4/1/05-03/31/08 ($290,000).（注：世界上第一个转基因干细胞治疗项目） Cytokine-modified stem cells in kidney transplantation. PI: 陈思锋

8. 国家自然科学基金面上项目:1993.1-1994.12，维生素D3和维甲酸降低血管通透性的机制，(39270789)，4.90（万）元,负责人：陈思锋

9. 国家自然科学基金面上项目:1995.1-1997.12，全身炎症时内皮细胞内维生素D3受体的变化及其调节(39470679) 6.0万,负责人：陈思锋

10. 国家自然科学基金面上项目:1997.1-1999.12，血管扩张时血管内皮细胞结构和功能的变化, (39600060) 9.50（万）元负责人：陈思锋

11. NIH/NIDDK R21 DK067472-01 6/1/04-5/31/06 ($290,000) .AAV type 1 and 5 vectors for gene delivery in the kidney. PI: Agarwal； Co-Investigator：陈思锋

12. NIH/NIDDK R01 DK59600 6/1/04-5/31/06 ($820,000). Human heme oxygenase-1 gene regulation in renal injury. Principal Investigator: Agarwal; Co-Investigator：陈思锋

13. 国际I型糖尿病协会重大项目 1/1/2001–12/31/2005 Principal Investigator: Mark A. Atkinson: “The JDFI Gene Therapy Center for the Prevention of Diabetes and Diabetic Complications at the University of Florida and the University of Miami”; Project 3: PI-Agarwal (分题$1.2 millions),Co-Investigator：陈思锋. K1-K3 angiostatin gene therapy for prevention of vascular endothelial cell proliferation and renal transplant loss.

14. NIH/NIDDK R01 07/01/2006-06/30/2011 ($1,818,750). Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection. Principal Investigator: Agarwal; Co-Investigator：陈思锋

十、发表论文

1. Meng Lu#; Rong Xue#; Pingping Wang; Xiaokai Wang; Xiaoyu Tian; Yingying Liu; Shun Wang; Anfeng Cui; Jingxin Xie; Lili Le; Meng Zhao; Jing Quan; Ning Li; Dan Meng; Xinhong Wang; Ning Sun; Alex F. Chen; Meng Xiang*; Sifeng Chen*; Induced pluripotent stem cells attenuate chronic allogeneic vasculopathy in an integrin beta-1-dependent manner. American Journal of Transplantation (accepted, online), American Journal of Transplantation.

2. 陈思锋.2019新型冠状病毒导致的致命肺渗漏的病理生理学机制和防治策略:兼论血透的应用与依据.《中国病理生理杂志》 2020,Vol.36（3）: 562-567.DOI: 10.3969/j.issn.1000-4718.2020.03.028

3. Meng Lu , Peng Lu , Ming Xu, Xiaokai Wang , Anfeng Cui , Yijun Li , Xinhong Wang , Dan Meng , Ning Sun , Meng Xiang, and Sifeng Chen. Enhanced wound healing promotion by immune response-free monkey autologous iPSCs and exosomes vs. their allogeneic counterparts. EBioMedicine. 2019 Apr;42:443-457.

4. Ruiting Sun, Yingying Liu, Meng Lu, Qianqian Ding, Pingping Wang, Heng Zhang, Xiaoyu Tian, Peng Lu, Dan Meng, Ning Sun, Meng Xiang, Sifeng Chen. ALIX Increases Protein Content and Protective Function of iPSC-derived Exosomes. J Mol Med (Berl). 2019 Jun;97(6):829-844.

5. Yang H, Wei L, Liu C, Zhong W, Li B, Chen Y, Han R, Zhuang J, Qu J, Tao H, Chen H, Xu C, Liang Q, Lu C, Qian R, Chen S, Wang W, Sun N. Engineering human ventricular heart tissue based on macroporous iron oxide scaffolds. Acta Biomater. 2019 Feb 16. pii: S1742-7061(19)30128-X. doi: 10.1016/j.actbio.2019.02.024. [Epub ahead of print]

6. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671.

7. Cui A, Xiang M, Xu M, Lu P, Wang S, Zou Y, Qiao K, Jin C, Li Y, Lu M, Chen AF, Chen S. VCAM-1-mediated neutrophil infiltration exacerbates ambient fine particle-induced lung injury. Toxicol Lett. 2019 Mar 1;302:60-74. doi: 10.1016/j.toxlet.2018.11.002. Epub 2018 Nov 15.

8. Q. DING, R. SUN, P. WANG, H. ZHANG, M. XIANG,D. MENG, N. SUN, A. F. CHEN and S. CHEN. Protective effects of human induced pluripotent stem cell‑derived exosomes on high glucose‑induced injury in human endothelial cells. Expermental and Therapeutic Medicine 2018;15: 4791-4797

9. Zhu W, Zhao M, Mattapally S, Chen S, Zhang J. Ccnd2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: Remuscularization of injured ventricle. Circulation research. 2018;122:88-96

19. Zhan Y, Sun X, Li B, Cai H, Xu C, Liang Q, Lu C, Qian R, Chen S, Yin L, Sheng W, Huang G, Sun A, Ge J, Sun N. Establishment of a prkag2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells. J Mol Cell Cardiol. 2018;117:49-61

11. Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X, Li X. Upregulation of hydroxysteroid sulfotransferase 2b1b promotes hepatic oval cell proliferation by modulating oxysterol-induced lxr activation in a mouse model of liver injury. Archives of toxicology. 2017;91:271-287

12. Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G, Liang P, Sun N. Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem cell research & therapy. 2017;8:202

13. Zhang H, Xiang M, Meng D, Sun N, Chen S. Inhibition of myocardial ischemia/reperfusion injury by exosomes secreted from mesenchymal stem cells. Stem cells international. 2016;2016:4328362

14. Xie J, Li X, Meng D, Liang Q, Wang X, Wang L, Wang R, Xiang M, Chen S. Transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft. Immunology letters. 2016;176:105-113

15. Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N. Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials. 2016;105:52-65

16. Wang L, Xiang M, Liu Y, Sun N, Lu M, Shi Y, Wang X, Meng D, Chen S, Qin J. Human induced pluripotent stem cells derived endothelial cells mimicking vascular inflammatory response under flow. Biomicrofluidics. 2016;10:014106

17. Luan L, Xue R, Lu C, Cui A, Hou Y, Quan J, Xiang M, Wang X, Yuan W, Sun N, Meng D, Chen S. Anti-serum with anti-autoantibody activity decreases autoantibody-positive b lymphocytes and type 1 diabetes of female nod mice. Autoimmunity. 2016;49:21-30

18. Kang X, Wei X, Wang X, Jiang L, Niu C, Zhang J, Chen S, Meng D. Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating notch signaling. Scientific reports. 2016;6:33737

19. Kang X, Wei X, Jiang L, Niu C, Zhang J, Chen S, Meng D. Nox2 and nox4 regulate self-renewal of murine induced-pluripotent stem cells. IUBMB life. 2016;68:963-970

20. Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, Yin L, Qian R, Chen S, Ling Z, Sun N. The roles of mesp family proteins: Functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein & cell. 2015;6:553-561

21. Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D. Bach1 represses wnt/beta-catenin signaling and angiogenesis. Circulation research. 2015;117:364-375

22. Gao Y, Meng D, Sun N, Zhu Z, Zhao R, Lu C, Chen S, Hua L, Qian R. Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochemical and biophysical research communications. 2014;443:586-591

23. Xu Y, Yang X, Wang Z, Li M, Ning Y, Chen S, Yin L, Li X. Estrogen sulfotransferase (sult1e1) regulates inflammatory response and lipid metabolism of human endothelial cells via ppargamma. Molecular and cellular endocrinology. 2013;369:140-149

24. Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, Xiang M, Wang X, Yuan W, Chen A, Meng D, Chen S. Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Clinical and experimental pharmacology & physiology. 2013;40:626-634

25. Le LL, Li XY, Meng D, Liang QJ, Wang XH, Li N, Quan J, Xiang M, Jiang M, Sun J, Chen SF. Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. CNS neuroscience & therapeutics. 2013;19:963-968

26. Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X, Chen S, Yin L, Li X. Effect of estrogen sulfation by sult1e1 and papss on the development of estrogen-dependent cancers. Cancer science. 2012;103:1000-1009

27. Shang Z, Lu C, Chen S, Hua L, Qian R. Effect of h(2)s on the circadian rhythm of mouse hepatocytes. Lipids in health and disease. 2012;11:23

28. Meng D, Mei A, Liu J, Kang X, Shi X, Qian R, Chen S. Nadph oxidase 4 mediates insulin-stimulated hif-1alpha and vegf expression, and angiogenesis in vitro. PloS one. 2012;7:e48393

29. Xiang M, Gu Y, Zhao F, Lu H, Chen S, Yin L. Mast cell tryptase promotes breast cancer migration and invasion. Oncology reports. 2010;23:615-619

30.Huang J, Lu C, Chen S, Hua L, Qian R. Postnatal ontogenesis of clock genes in mouse suprachiasmatic nucleus and heart. Lipids in health and disease. 2010;9:22

31. Xu C, Lu C, Hua L, Jin H, Yin L, Chen S, Qian R. Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein e knockout mice. The Canadian journal of cardiology. 2009;25:473-479

32. Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM. Microrna-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clinical and experimental pharmacology & physiology. 2009;36:181-188

33. Wang XH, Chen SF, Jin HM, Hu RM. Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats. Life sciences. 2009;84:240-249

34. Ning Y, Xu L, Ren S, Pandak WM, Chen S, Yin L. Star overexpression decreases serum and tissue lipids in apolipoprotein e-deficient mice. Lipids. 2009;44:511-519

35. Ning Y, Bai Q, Lu H, Li X, Pandak WM, Zhao F, Chen S, Ren S, Yin L. Overexpression of mitochondrial cholesterol delivery protein, star, decreases intracellular lipids and inflammatory factors secretion in macrophages. Atherosclerosis. 2009;204:114-120

36. Hou L, Lu C, Huang Y, Chen S, Hua L, Qian R. Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein e knock-out atherosclerotic mice. Lipids in health and disease. 2009;8:60

37. Zhang X, Zhao F, Xu C, Lu C, Jin H, Chen S, Qian R. Circadian rhythm disorder of thrombosis and thrombolysis-related gene expression in apolipoprotein e knock-out mice. International journal of molecular medicine. 2008;22:149-153

38. Zhang W, Wang XH, Chen SF, Zhang GP, Lu N, Hu RM, Jin HM. Biphasic response of endothelial progenitor cell proliferation induced by high glucose and its relationship with reactive oxygen species. The Journal of endocrinology. 2008;197:463-470

39. Zhang W, Wang X, Jin H, Qian R, Zhang G, Chen S, Hu R. Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2008;57:571-576

40. Wang L, Zhou X, Zhou T, Ma D, Chen S, Zhi X, Yin L, Shao Z, Ou Z, Zhou P. Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. Journal of cancer research and clinical oncology. 2008;134:365-372

41. Zhou P, Zhi X, Zhou T, Chen S, Li X, Wang L, Yin L, Shao Z, Ou Z. Overexpression of ecto-5'-nucleotidase (cd73) promotes t-47d human breast cancer cells invasion and adhesion to extracellular matrix. Cancer biology & therapy. 2007;6:426-431

42. Zhi X, Chen S, Zhou P, Shao Z, Wang L, Ou Z, Yin L. Rna interference of ecto-5'-nucleotidase (cd73) inhibits human breast cancer cell growth and invasion. Clinical & experimental metastasis. 2007;24:439-448

43. Wang XH, Zhang GP, Jin HM, Chen SF. Dynamic changes in the expression of growth factor receptors in the myocardium microvascular endothelium after murine myocardial infarction. Chinese medical journal. 2007;120:485-490

44. Wang XF, Shao Y, Chen SW, Tian DZ, Huang GY, Huang Y, Yao T, Lu LM. Amelioration of cardiac function in chronic myocardial infarcted rats following administration of vector pcdna3.1am. Clinical and experimental pharmacology & physiology. 2007;34:861-865

45. Ning Y, Chen S, Li X, Ma Y, Zhao F, Yin L. Cholesterol, ldl, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bend.3). Biochemical and biophysical research communications. 2006;342:1249-1256

46. Chen SW, Wang XF, Shao Y, Xue H, Zhou L, Yao T, Lu LM. Similar effects on rat renal mesangial cells by expressing different fragments of adrenomedullin gene in vitro. Acta pharmacologica Sinica. 2005;26:845-85

47. Curtis LM, Chen S, Chen B, Agarwal A, Klug CA, Sanders PW. Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation technique. American journal of physiology. Renal physiology. 2008;295:F310-314

48. Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S. Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007;7:1112-1120

49. Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, Li Calzi S, Lach R, Hock TD, Chen B, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant MB, Agarwal A. Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. The Journal of experimental medicine. 2007;204:605-618

50. Chen S, Wasserfall C, Kapturczak MH, Atkinson M, Agarwal A. Freeze-thaw increases adeno-associated virus transduction of cells. American journal of physiology. Cell physiology. 2006;291:C386-392

51. Kapturczak MH, Chen S, Agarwal A. Adeno-associated virus vector-mediated gene delivery to the vasculature and kidney. Acta biochimica Polonica. 2005;52:293-299

52. Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:7251-7256

53. Chen S, Kapturczak M, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Campbell-Thompson M, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human gene therapy. 2005;16:235-247

54. Chen S, Sega M, Agarwal A. 'Lumen digestion' technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice. BioTechniques. 2004;37:84-86, 88-89

55. Chen S, Agarwal A, Glushakova OY, Jorgensen MS, Salgar SK, Poirier A, Flotte TR, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology : JASN. 2003;14:947-958

56. Mainwaring MG, Rimsza LM, Chen SF, Gomez SP, Weeks FW, Reddy V, Lynch J, May WS, Kahn S, Moreb J, Leather H, Braylan R, Rowe TC, Fieniewicz KJ, Wingard JR. Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (t-em) and correlation with topoisomerase ii levels. Leukemia & lymphoma. 2002;43:989-999

57. Chen S, Gomez SP, McCarley D, Mainwaring MG. Topotecan-induced topoisomerase iialpha expression increases the sensitivity of the cml cell line k562 to subsequent etoposide plus mitoxantrone treatment. Cancer chemotherapy and pharmacology. 2002;49:347-355

58. Chen S, Patel JM, Block ER. Angiotensin iv-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release. American journal of physiology. Lung cellular and molecular physiology. 2000;279:L849-856.

59. Chen SF, Fei X, Li SH. A new simple method for isolation of microvascular endothelial cells avoiding both chemical and mechanical injuries. Microvascular research. 1995;50:119-128

60. Chen SF, Ruan YJ. 1 alpha,25-dihydroxyvitamin d3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema. Pharmacology & toxicology. 1995;76:365-367

61. Chen SF. The effects of platelet activating factor and retinoic acid on the expression of elam-1 and icam-1 and the functions of neutrophils. Mediators of inflammation. 1995;4:103-106

62. Chen SF. 1 alpha, 25-dihydroxyvitamin d3 decreased icam-1 and elam-1 expressions on pulmonary microvascular endothelial cells and neutrophil motivation. The Journal of steroid biochemistry and molecular biology. 1995;52:67-70

63. Chen SF, Li SH, Ding FY. Three drugs inhibit phospholipase a2-induced high permeability of endothelial monolayers. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1994;15:299-302

64. Li SH, Fei X, Chen SF, Ding ZQ, Wu ZL. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1994;15:219-222

65. Chen SF, Li SH, Fei X, Wu ZL. Phospholipase a2-induced lung edema and its mechanism in isolated perfused guinea pig lung. Inflammation. 1990;14:267-273

66. 陈思锋，姜远英，张凤斋，朱铨英，钟纪根，张金山。萎胃安对大鼠慢性萎缩性胃炎的预防和治疗作用。药学实践杂志 1998.11.15; 16(6): 328-330。

67. Hu N, Chen SF and Yu B. The mechanisms of ET-1-induced lung edema. Chung Hua I Hsueh Tsa Chih (Chin J Med) 1996:76:694.

68. Li SH, Dong Y and Chen SF. The effects of phospholipase A2 on endotoxin-induced rat lung injury. Chin J Appl Physiol 1994; 10:105.

69. 李少华, 董艳, 陈思锋, 丁自强, 吴中立。磷脂酶A2在内毒素致大鼠肺损伤的作用。中国应用生理学杂志 1994.05.28; 10(2): 105。

70. Chen SF and Li SH. leukocyte-endothelium adhesion decreases the permeability of microvascular endothelial monolayers. Chin J Physiol Sci 1993; 9(3):201. (in English)

71. Chen SF and Li SH. Leukocytes regulate platelet activating factor-induced lung injury in isolated perfused rat lungs. Chin J Physiol Sci 1993; 9(3):208. (in English).

72. 陈思锋; 费侠; 李少华。血小板激活因子所致的大鼠肺损伤依赖于细胞外钙离子的存在。第二军医大学学报 1993; 14(4): 327-330。

73. Li SH, Zhang HH and Chen SF. Platelet activating factor mediates endotoxin-induced lung injury and its mechanism. J Med Coll PLA(Chinese Army) 1992; 7(4):374. (in English).

74. 李少华，陈思锋，费侠，丁自强，吴中立。血小板激活因子在内毒素致狗急性肺损伤中的作用及其机理。第二军医大学学报 1992; 13(2): 111-115。

75. 陈思锋。狗磷脂酶A2与白细胞活性的关系。基础医学与临床 1992; 12(5): 26-28。

76. Chen SF, Li SH and Wu ZL. Effects of platelet activating factor and SRI 63-441 on pulmonary vascular permeability and resistances in isolated perfused rat lungs. Chin J Physiol Sci 1991; 7(2):157. (in English).

77. 陈思锋。用大鼠离体灌流肺测定肺血管通透性和血管阻力。中国应用生理学杂志 1991; 7(2): 155-157。

78. 丁自强，吴中立，陈思锋。急性胰腺炎狗肺表面活性物质系统的损伤及其机理。第二军医大学学报 1990; 11(1): 10-14。

79. Ding ZQ, Wu ZL and Chen SF. pulmonary surfactant system defects and their mechanism in acute pancreatitis. Chin J Med 1989; 10(5):433 . (in English).

80. 陈思锋，吴中立，丁自强，王琪，李少华。狗急性胰腺炎时磷脂酶A2的变化及其在急性肺损伤中的作用。第二军医大学学报 1989; 10(2): 105-109。

81. 陈思锋，吴中立。体液和组织磷脂酶A2的简便快速测定法。第二军医大学学报 1989; 10(3): 254-256。杨义力，陈思锋。糖皮质激素对大鼠血清磷脂酶A2的张力性抑制。第二军医大学学报 1989; 10(1): 29-30,24。

十一、学术专著（作为主编或副主编）

1. 副主编：《人体病理生理学》第3版，人民卫生出版社，300万字， 2019

2. 主编：《病理生理学》，复旦大学出版社，2015

3. 共同主编：《高级临床病理生理学》，复旦大学出版社，2010

4. Chen SF, et al. Gene therapy for kidney diseases. In: Laboratory Techniques in Biochemistry and Molecular Biology: Adeno-associated Viral Vectors for Gene Therapy. 31: 161-191; 2005.

十二、授权专利

胰岛素与血清蛋白可逆性结合的亲和力指标测定方法及应用，201110184366.5，陈思锋，陆超，栾丽娟，张雪晴，侯彦强，孟丹，李晓波，向萌，王丽，赵风娣

申请中专利多项。

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陈思锋教授

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