Abstract: China is one of the major countries manufacturing and using micro(nano)plastics and antibiotics. However, owing to the overuse by human beings and low-efficient removal of micro(nano)plastics and antibiotics by the most wastewater treatment facilities, large quantities of micro(nano)plastics and antibiotics have entered the aquatic environment, posing a huge potential threat to the ecological environment and human health. With adsorbing antibiotics via a variety of physicochemical interactions and further transferring them into organisms, micro(nano)plastics can damage the intestinal, liver, nervous and reproductive systems of aquatic organisms, which later can be enriched and migrated through the food chain and finally affect human health. In this review, we summarized the interaction between micro(nano)plastics and antibiotics and their joint toxic effects on fish in detail and prospected the future research directions of the mechanism of their joint interactions. This review provides a comprehensive survey and theoretical guidance for the future investigations on evaluation of the environmental risks of micro(nano)plastics and antibiotics.