博士 起止时间：1990-1993，毕业院校：山东大学，专业：微生物学
硕士 起止时间：1987-1990，毕业院校：山东农业大学，专业：真菌学
学士 起止时间：1983-1987，毕业院校：山东大学，专业：微生物学
工作经历
起止时间 单位名称 专业技术职务
1993-1995 中科院沈阳应用生态所 博士后
1995-2000 山东大学微生物技术国家重点实验室 副教授
1996.4-1996.10 德国国家生物技术研究中心（GBF） 高级访问学者
2000-今 山东大学微生物技术国家重点实验室 教授
研究方向
黏细菌（Myxobacteria）在系统进化上属于Proteobacteria类群的δ分支。在其生活史中表现复杂的多细胞群体行为特性，显示与多细胞真核生物较多的相似性，显著不同于其他细菌，被认为是生活于多细胞生命边缘的单细胞生物类群，是一类“高等”的原核生物，是细菌细胞间通讯与协作，多细胞形态发生，以及生命进化等研究的重要模式生物材料。黏细菌能够降解利用其他活的微生物细胞、细胞残体以及许多难降解的大分子有机物，是一类捕食性细菌，在微生物生态系统扮演重要角色。黏细菌拥有庞大的基因组，是目前报道的原核生物中最大的。黏细菌能够产生丰富的次级代谢产物，具有种类多、结构新、作用机理新颖多样的特性，被公认是继放线菌之后又一个重要的药源微生物新类群。
我们以黏细菌为基本材料，开展如下方面的研究：
1.黏细菌资源及其多样性，包括可培养和未培养的黏细菌类群；
2.以黏细菌资源为基础，开展黏细菌细胞行为及其进化研究；
3.以黏细菌产生的抗肿瘤化合物埃博霉素（Epothilones）为主要研究对象，开展黏细菌发酵工程和代谢工程研究；
4.在黏细菌中建立和改进遗传操作体系，并对黏细菌进行遗传分析和遗传改造。
代表性论文（近五年）
Tian-yu Wan, Li Zhuo*, Zhuo Pan, Rui-yun Chen, Han Ma, Ying Cao, Jianing Wang, Jing-jing Wang, Wei-feng Hu, Ya-jun Lai, Muhammad Hayat, Yue-zhong Li*. Dosage constraint of the ribosome-associated molecular chaperone drives the evolution and fates of its duplicates in bacteria.mBio. 2024. accepted.
Tian-yu Wan, Ying Cao, Ya-jun Lai, Zhuo Pan, Yue-zhong Li*, Li Zhuo*. Functional investigation of the two ClpPs and three ClpXs inMyxococcus xanthusDK1622.mSphere. 2024. e00363-24.
Hu W, Yang J, Wang J, Yuan S, Yue X, Zhang Z, Zhang Y, Meng J, Li Y*. Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria.mSystems. 2024. 9: e01210-23.
Yue, X. J.*, Wang, J. R., Zhao, J. N., Pan, Z., Li, Y. Z.*. Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells.Synthetic and Systems Biotechnology. 2024. 9(3), 540-548.
Li, D. D.#, Wang, J.#, Jiang, Y., Zhang, P., Liu, Y., Li, Y. Z.*, Zhang, Z.*. Quantifying functional redundancy in polysaccharide-degrading prokaryotic communities.Microbiome. 2024. 12(1), 120.
Wang, C. Y., Hu, J. Q., Wang, D. G., Li, Y. Z.*, Wu, C*. Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023.Natural Product Reports. 2024. 41(6), 905–934.
Zhu, L. L.#, Yang, Q.#, Wang, D. G.#, Niu, L., Pan, Z., Li, S., Li, Y. Z.*, Zhang, W.*, Wu, C.*. Deciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria.ACS Central Science. 2024. 10(3), 555-568.
Pan, Z.#, Li, D. D.#, Li, P., Geng, Y., Jiang, Y., Liu, Y., Li, Y. Z.*, Zhang, Z*. GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere.Nucleic Acids Research. 2024. 52(D1), D724-D731.
Pan, Z., Zhuo, L., Wan, T. Y., Chen, R. Y., Li, Y. Z.*. DnaK duplication and specialization in bacteria correlates with increased proteome complexity.mSystems. 2024. 9(4): e0115423.
Ran, Q., Du, X., Han, L., Wang, J.*, Li, Y. Z*. Three novel species of the genus Flavobacterium, Flavobacterium odoriferum sp. nov., Flavobacterium fragile sp. nov. and Flavobacterium luminosum sp. nov., isolated from activated sludge.International Journal of Systematic and Evolutionary Microbiology. 2024. 74(2), 10.1099/ijsem.0.006258.
Yuan, S. F., Yue, X. J.*, Hu, W. F., Wang, Y., Li, Y. Z.*. Genome-wide analysis of lipolytic enzymes and characterization of a high-tolerant carboxylesterase fromSorangium cellulosum.Frontiers in Microbiology. 2023. 14, 1304233.
Xin-jing Yue*, Duo-hong Sheng, Li Zhuo, Yue-zhong Li*. Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism.Engineering Microbiology. 2023, 3, 100075.
Jianing Wang*, Zhuo Pan, Jianshui Yu, Zheng Zhang, Yue-zhong Li*. Global assembly of microbial communities.mSystems. 2023, 8: e01289-22.
Degao Wang#, Chaoyi Wang#, Jiaqi Hu#, Jingjing Wang#, Wenchao Liu, Wenjuan Zhang, Xinran Du, Han Wang,Lele Zhu, Haiyan Sui, Yue-zhong Li*, Changsheng Wu*. Constructing a Myxobacterial Natural Product Database to Facilitate NMR-Based Metabolomics Bioprospecting of Myxobacteria.Analytical chemistry. 2023, 95, 5256-5266.
Dan-Dan Li, Zheng Zhang*, Jia-Ning Wang, Peng Zhang, Ya Liu, Yue-Zhong Li*. Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities.Environmental Microbiology. 2022 Nov 29.
Ya Liu, Sheng Liu, Zhuo Pan, Yu Ren, Yiru Jiang, Feng Wang, Dan-Dan Li, Yue-Zhong Li*, Zheng Zhang*. PAT: a comprehensive database of prokaryotic antimicrobial toxins.Nucleic Acids Research. 2022 Oct 16: gkac879.
Xinran Du, Qi Ran, Jianing Wang, Hong Jiang, Jingjing Wang*, Yue-Zhong Li*. Microvirga roseola sp. nov. and Microvirga lenta sp. nov., isolated from Taklamakan Desert soil.International Journal of Systematic and Evolutionary Microbiology. 2022 Jun;72(6).
Li Zhuo, Tian-Yu Wan, Zhuo Pan, Jia-Ning Wang, Duo-Hong Sheng, Yue-Zhong Li*. A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of Duplicate groELs and Plays a Global Regulatory Role in Myxococcus.mSystems. 2022 Apr 26; 7(2): e0105621.
Shuge Wu, Jingjing Wang*, Jianing Wang, Xinran Du, Qi Ran, Qi Chen, Duohong Sheng, Yue-Zhong Li*. Halalkalibacterium roseum gen. nov., sp. nov., a new member of the family Balneolaceae isolated from soil.International Journal of Systematic and Evolutionary Microbiology. 2022 Apr; 72(4).
Changsheng Wu*,#, Yinzhen Yin#, Le-Le Zhu, Youming Zhang, Yue-Zhong Li*. Metagenomic Sequencing Driven Multidisciplinary Approaches to Shed Light on The Untapped Microbial Natural Products.Drug Discovery Today2022 Mar; 27(3): 730-742.
Li-Juan Zhang, De-Gao Wang, Peng Zhang, Changsheng Wu*, Yue-Zhong Li*. Promiscuity Characteristics of Versatile Plant Glycosyltransferases for Natural Product Glycodiversification.ACS Synthetic Biology. 2022 Feb 18; 11(2): 812-819.
Peng Zhang, Lijuan Zhang, Xukai Jiang, Xiao-Tong Diao, Shuang Li, Dan-Dan Li, Zheng Zhang, Junqiang Fang, Ya-Jie Tang, Da-Lei Wu, Changsheng Wu*, Yue-Zhong Li*. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B.Communications Biology. 2022 Jan 27; 5(1): 100.
Zheng Zhang#,*, Ya Liu#, Peng Zhang, Jianing Wang, Dandan Li, Yue-zhong Li*. PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes.mSystems2021 Dec 21; 6(6): e0095321.
Dan-dan Li, Jin-lan Wang, Ya Liu, Yue-zhong Li*, Zheng Zhang*. Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases.Computational and Structural Biotechnology Journal2021 Nov 2; 19: 5931-5942.
Wei-Feng Hu#, Luo Niu#, Xin-jing Yue, Le-Le Zhu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Characterization of Constitutive Promoters for The Elicitation of Secondary Metabolites in Myxobacteria.ACS Synthetic Biology2021, 10, 2904−2909.
De-Gao Wang#, Luo Niu#, Zhao-Min Lin, Jing-Jing Wang, Dong-Fang Gao, Hai-Yan Sui, Yue-Zhong Li*, Changsheng Wu*. The Discovery and Biosynthesis of Nicotinic Myxochelins from an Archangium sp. SDU34.Journal of Natural Products2021, 84, 2744−2748.
Ye Wang, Xin-jing Yue*, Shu-fei Yuan, Yu Hong, Wei-feng Hu, Yue-zhong Li*. Internal promoters and their effects on the transcription of operon genes for the epothilone production in Myxococcus xanthus.Frontiers in Bioengineering and Biotechnology2021 Oct 27;9. doi: 10.3389/fbioe.2021.758561
Jingjing Wang, Qi ran, Xinran Du, Shuge Wu, Jianing Wang, Duohong Sheng, Qi Chen, Zongjun Du, Yue-zhong Li*. Two new Polyangium species, P. aurulentum sp. nov. and P. jinanense sp. nov., isolated from a soil sample.Systematic and Applied Microbiology2021, 44, 126274.
Duohong Sheng#, Xiaojing Chen#, Yajie Li, Jingjing Wang, Li Zhuo, Yue-zhong Li*. ParC, a new partitioning protein, is necessary for the active form of ParA from Myxococcus pMF1 plasmid.Frontiers in Microbiology2021, 11:623699.
Yuelan Li#, Li Zhuo#, Xiaobin Li, Yongqiang Zhu, Shuge Wu, Wei Hu, Tao Shen, Yue-Zhong Li*, changsheng Wu*. Myxadazoles, myxobacterium-derived isoxazole-benzimidazole hybrids with cardiovascular activities.Angewandte Chemie International Edition2021, 60, 21679 –21684.
Jingjing Wang#, Jianing Wang#, Shuge Wu, Zheng Zhang*, Yue-zhong Li*. Global geographic diversity and distribution of the myxobacteria.Microbiology Spectrum2021, 9: e00012-21.
Jianing Wang, Lidong Wang, Weifeng Hu, Zhuo Pan, Peng Zhang, Chuandong Wang, Jingjing Wang, Shuge Wu, Yue-zhong Li*. Assembly processes and source tracking of planktonic and benthic bacterial communities in the Yellow River estuary.Environmental Microbiology2021, 23(5), 2578–2591.
Jia-Qi Hu#, Jing-Jing Wang#, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combine NMR-basedmetabolic profiling andgenome mining for the accelerated discovery of archangiumide, an allenic macrolide from the myxobacteriumArchangium violaceum SDU8.Organic Letters2021, 23, 2114−2119.
Ya Liu, Jianing Wang, Zheng Zhang, Feng Wang, Ya Gong, Duo-hong Sheng, Yue-zhong Li*. Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in Myxococcus xanthus.Applied and Environmental Microbiology2021, 87: e00080-21.
Duohong Sheng*, Ye Wang, Zhiwei Jiang, Dongkai Liu, Yuezhong Li*. ImuA facilitates SOS mutagenesis by inhibiting RecA-mediated activity in Myxococcus xanthus.Applied and Environmental Microbiology2021, doi:10.1128/AEM.00919-21.
Zhuo Pan, Zheng Zhang, Li Zhuo, Tian-yu Wan, Yue-zhong Li*. Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus.mSphere2021, 6: e00305-21.
Duo-hong Sheng#*, Ye Wang#, Shu-ge Wu, Rui-xin Duan, Yue-zhong Li*. The regulation of LexA on UV induced SOS response in Myxococcus xanthus based on transcriptome analysis.Journal of Microbiology and Biotechnology, 2021, 31(6).
Zheng Zhang#*, Jianing Wang#, Jinlan Wang, Jingjing Wang, Yuezhong Li*. Estimate of the sequenced proportion of the global prokaryotic genome.Microbiome. 2020 Sep 16;8(1):134.
Wang, J. N., Wang, J. J., Zhang, Z., Li, Z., Li, Y. Z*. Shifts in the Bacterial Population and Ecosystem Functions in Response to Vegetation in the Yellow River Delta Wetlands.mSystems, 2020, 5(3): e00412-20
Y Liu, Z Zhang, F Wang, DD Li, YZ Li*. Identification of type VI secretion system toxic effectors using adaptors as markers.Computational and Structural Biotechnology Journal, 2020, 18(6):3723-3733.
DH Sheng, YX Wang, M Qiu, JY Zhao, YZ Li*. Functional Division Between the RecA1 and RecA2 Proteins in Myxococcus xanthus.Frontiers in Microbiology, 2020, 11:140.
XJ Chen, Z Zhang, YJ Li, L Zhuo, DH Sheng, YZ Li*. Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02.FEMS Microbiology Ecology, 2020(3):3.
Peng Zhang, Lijuan Zhang, Xin-jing Yue, Ya-jie Tang, Changsheng Wu*, Yue-zhong Li*. Effects of glycosylation on the bioactivity of rapamycin.Applied Microbiology and Biotechnology, 2020, 104(21):9125–9134
SG Wu, JJ Wang, JN Wang, Q Chen, YZ Li*. Psychroflexus aurantiacus sp. nov. isolated from soil in the Yellow River Delta wetlands.International Journal of Systematic and Evolutionary Microbiology, 2020, 70(12).
SG Wu, JJ Wang, JN Wang, Q Chen, YZ Li*. Paucihalobacter ruber gen. nov. sp. nov. isolated from a haloalkaline lake sediment sample.International Journal of Systematic and Evolutionary Microbiology, 2020, 70(10).
JJ Wang, SG Wu, Q Chen, DH Sheng, YZ Li*. Deinococcus terrestris sp. nov. a gamma ray- and ultraviolet-resistant bacterium isolated from soil.International Journal of Systematic and Evolutionary Microbiology, 2020, 70(9).
Peng Zhang, Zheng Zhang, Zhi-feng Li, Qi Chen, Yao-yao Li, Ya Gong, Xin-jing Yue, Duo-hong Sheng, You-ming Zhang, Changsheng Wu*, Yue-zhong Li*. Phylogeny-guided characterization of glycosyltransferases for epothilone glycosylation.Microbial Biotechnology, 2019, 12(4), 763-774
Mian Nabeel Anwar, Zhi Feng Li, Gong Ya, Raghvendra Partap Singh, Yue-zhong Li*. Omics studies revealed the factors involved in the formation of colony boundary in Myxococcus xanthus.Cells, 2019, 8, 530.
获奖情况
山东省科技发明二等奖（2006）
国家杰出青年科学基金资助（2008）
“百千万”工程国家级人才（2009）
教育部高等学校自然科学一等奖（2017）
山东省首批领军人才创新工作室（2017）