一款1.1类创新药物获中美临床批件，当前在临床实验。
近期发表文章 （*corresponding author）
2022
1. Zhe Jing, Shuqing Wang, Keyuan Xu, Qian Tang, Wenjing Li, Wei Zheng, Haobo Shi, Kailing Su, Yanting Liu*, Zhangyong Hong*. A potent micron neoantigen tumor vaccine GP-Neoantigen induces robust antitumor activity in multiple tumor models. Adv. Sci., 2022, 2201496.
2. Lichun Wang , Yu Ding, Nan Li, Yamin Chai, Qiyu Li, Yunzheng Du, Zhangyong Hong, Lailiang Ou. Nanobody-based polyvinyl alcohol beads as antifouling adsorbents for selective removal of tumor necrosis factor- α. Chin. Chem. Lett., 2022, 33, 2512-2516.
2021
1. Yutong Xing, Keyuan Xu, Shixiong Li, Li Cao, Yue Nan, Qiyu Li, Wenjing Li and Zhangyong Hong*. A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy. Int. J. Mol. Sci., 2021, 22, online.
2. Wenjing Li, Zhe Jing, Shuqing Wang, Qiyu Li, Yutong Xing, Haobo Shi, Shuang Li*, Zhangyong Hong*. P22 Virus-like Particles as an effective antigen delivery nanoplatform for cancer immunotherapy. Biomaterials, 2021, 271, 120726.
3. Yonghui Liu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin, Kun Wang, Zhangyong Hong*, Wei Zhao*. Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine. Chinese Chem. Lett., 2021, 32, 6, 1963-1966.
4. Hui Liu, Ziyu Meng, Hesuiyuan Wang, Shuo Zhang, Zhen Huang, Xiaofang Geng, Rui Guo, Zhenzhou Wu*, Zhangyong Hong*. Robust immune responses elicited by a hybrid adjuvant based on β-glucan particles from yeast for the hepatitis B vaccine. ACS Appl. Bio Mater. 2021, 4, 4, 3614–3622.
5. Qiyu Li, Wenjing Li, Keyuan Xu, Yutong Xing, Haobo Shi, Zhe Jing, Shuang Li* and Zhangyong Hong*. PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates. Int. J. Mol. Sci. 2021, 22, 1540, 1-18.
6. Qiyu Li, Wenjing Li, Keyuan Xu, Yutong Xing, Yu Ding, Zhe Jing, Xi Wang, Zhangyong Hong*. Preclinical evaluation of a novel anti-mesothelin immunotoxin based on a single domain antibody as the targeting ligand. Int. J. Pharm., 2021, online.
2020
1. Li Cao, Qiyu Li, Zhen Tong, Yutong Xin, Keyuan Xu, Jessica Yijia Wang, Wenjing Li, Jianhua Zhao, Liqing Zhao, Zhangyong Hong*. HER2-specific immunotoxins constructed based on single-domain antibodies and the improved toxin PE24X7. Int. J. Pharm., 2020, 574, 118939 (online).
2. Shuang Li, Yingying Jin, Yao Su, Wenjing Li, Yutong Xing, Fengwei Wang*, Zhangyong Hong*. Anti-HER2 Affibody-Conjugated Photosensitizer for Tumor Targeting Photodynamic Therapy. Mol. Pharm., 2020, 17, 5, 1546–1557.
2019
1. Qian Liu, Jin Wang, Shuang Li, Guojie Li, Qingle Chen, Zhangyong Hong.* Folate-Targeted Polyethylene Glycol-Modified Photosensitizers for Photodynamic Therapy. J. Pharm. Sci., 2019, 108, 2102-2111.
2. Yu Wei, Wei Li, Tengfei Du, Zhangyong Hong*, Jianping Lin*. Targeting HIV/HCV Coinfection Using a Machine Learning-Based Multiple Quantitative Structure-Activity Relationships (Multiple QSAR) Method. Int. J. Mol. Sci., 2019, 20, 14.
3. Jisi Zhao, Shuang Li, Yingying Jin, Jessica Yijia Wang, Wenjing Li, Wenjie Wu*, Zhangyong Hong*. Multimerization Increases Tumor Enrichment of Peptide-Photosensitizer Conjugates. Molecules, 2019, 24, 4.
4. Zhiyou Zong, Qiyu Li, Zhangyong Hong, Haohao Fu, Wensheng Cai,* Christophe Chipot, Huifeng Jiang, Dongyuan Zhang, Shulin Chen, Xueguang Shao.* Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases. J. Am. Chem. Soc., 2019, 141(36), 14451-14459. DOI: 10.1021/jacs.9b08477.
2018
1. Yu Wei, Jinlong Li, Baiqing Li, Chunfeng Ma, Xuanming Xu, Xu Wang, Aqin Liu, Tengfei Du, Zhonghua Wang*, Zhangyong Hong,* Jianping Lin.* GCDB: a glaucomatous chemogenomics database for in silico drug discovery. Database, 2018, 1–14.
2. Feng F, Chen X, Li G, Liang S, Hong Z, Wang HF. Afterglow Resonance Energy Transfer Inhibition for Fibroblast Activation Protein-α Assay. ACS Sens., 2018, 28; 1846-1854. doi: 10.1021/acssensors.8b00680. Epub 2018 Sep 18.
3. Hui Liu, Zhenghu Jia, Chengmao Yang, Mei Song, Zhe Jin , Zhenzhou Wu, Liqing Zhao, Dongsheng Wei,* Zhinan Yin,* Zhangyong Hong,* Aluminum hydroxide colloid vaccine encapsulated in yeast shell with enhanced humoral and cellular immunity response. Biomaterials, 2018, 167, 32-43.
4. Wenjing Li, Sihai Tan, Yutong Xing, Qian Liu, Shuang Li, Qingle Chen, Min Yu,* Fengwei Wang,* Zhangyong Hong,* cRGD peptide conjugated pyropheophor¬bide-a photosensitizers for tumor targeting photodynamic therapy. Mol. Pharm., 2018， 15， 1505-1514.
5. Kai Wang,* Yupeng Feng, Shuang Li, Wenjing Li, Xi Chen, Ran Yi, Hongru Zhang, Zhangyong Hong,* Oral delivery of bavachinin-loaded PEG-PLGA nanoparticles for asthma treatment in a murine model. J. Biomed. Nanotech., 2018, accepted.
6. Qingle Chen, Yanhong Ma, Jisi Zhao, Mei Zhao, Wenjing Li, Qian Liu, Li Xiong,* Wenjie Wu,* and Zhangyong Hong*, In vitro and in vivo evaluation of improved EGFR targeting peptide-conjugated phthalocyanine photosensitizer for tumor photodynamic therapy. Chinese Chem. Lett., special issue，2018, accepted.
7. Q. Liu, M. Pang, S. Tan, J. Wang, Q. Chen, K. Wang,* W. Wu* and Z. Hong*. Potent peptide-conjugated silicon phthalocyanines for tumor photodynamic therapy. J. Cancer., 2018. 2018; 9(2): 310-320.
8. Min Yu, Ke Wang, Han Zhang, Qian Liu, Jin Wang, Li Cao, Wenjing Li, Kai Wang,* Zhangyong Hong,* DOTAP-incorporated PEG-PLGA nanoparticles for efficient in vitro and in vivo gene delivery. J. Biomed. Nanotech. 2018, 14, 281–293.
2017
1. Z. Chen, F. Liu, Y. Chen, J. Liu, X. Wang, A. T. Chen, G. Deng, H. Zhang, J. Liu, Z. Hong,* and J. Zhou.* Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles. Adv. Funct. Mater., 2017, 1703036 (online).
2. Z. Yang, M. Xu, Z. Jia, Y. Zhang, L. Wang, H. Zhang, J. Wang, M. Song, Y. Zhao, Z. Wu, L. Zhao*, Z. Yin* and Z. Hong*. A novel antigen delivery system induces strong humoral and CTL immune responses. Biomaterials, 2017, 134, 51-63.
3. J. Wang, Q. Liu, Y. Zhang, H. Shi, H. Liu, W. Guo, Y. Ma, W. Huang* and Z. Hong*. A pyropheophorbide a-based photosensitizer tested for in vivo targeted photodynamic therapy. J. Pharmaceutic Sciences, 2017, 106, 1482-1489.
4. J. Wang, X. Cao, H. Zhao, J. Zhao, J. Wei, Q, Li, X. Qi, Z. Yang, L. Wang, H. Zhang, L. Bai, Z. Wu, L. Zhao, Z. Hong* and Z. Yin*. Critical roles of conventional dendritic cells in promoting T cell dependent hepatitis through regulating NKT cells. Clinical and Experimental Immunology, 2017, 188, 127-137.
2016
1. H. Jiang, Z. Liang, Y. Ma, D. Kong* and Z. Hong*. G-quadruplex fluorescent probe-mediated real-time rolling circle amplification strategy for highly sensitive microRNA detection. Analytica Chimica Acta, 2016, 114-122.
2. R. Guo, L Cao, W. Guo, H. Liu, H. Xu, Q. Fang* and Z Hong*. HER2-targeted immunotoxins with low nonspecific toxicity and immunogenicity. Biochemical and Biophysical Research Communications, 2016, 475, 93–99.
3. R. Guo, W. Guo, L. Cao, H. Liu, J. Liu, H. Xu, W. Huang,* F. Wang* and Z. Hong.* Fusion of the albumin binding domain to extend the half-life of immunotoxin. Int. J. pharm., 2016, 511, 538-549.
4. H. Liu, M. Zhao, J. Wang, M. Pang, Z. Wu, L. Zhao, Z. Yin* and Z. Hong*. Photodynamic therapy of tumors with Pyro-loaded PEG-PLGA nanoparticles. Int. J. Nanomed., 2016, 4905-4918.
5. F. Li, Q. Liu, Z. Liang, J. Wang, M. Pang, W. Huang, W. Wu*, and Z. Hong*. Synthesis and biological evaluation of peptide-conjugated phthalocyanine photosensitizer with highly hydrophilic modifications. Org. Biomol. Chem., 2016, 14, 3409-3422.
2015
1. Y.-R, Li, Q. Liu, Z. Hong, H.–F. Wang.* Magnetic Separation-assistant Fluorescence Resonance Energy Transfer Inhibition for High Sensitive Probing of Nucleolin. Anal. Chem., 2015, 87 (24), pp 12183–12189.
2. S. Chen, J. Wang, H. Cheng, W. Guo, M. Yu, Z. Zhao, Z. Wu, L. Zhao, Z. Yin*, Z. Hong*. Targeted delivery of NK007 to macrophages to treat colitis. J. Pharmaceutical Sciences, 2015, 104, 2276–2284.
3. Y. Li, J. Wang, X. Zhang, W. Guo, F. Li, M. Yu, X. Kong, W. Wu, Z*. Hong*. Highly water-soluble and tumor-targeted photosensitizers for photodynamic therapy. Org. Biomol. Chem., 2015, 13, 7681-7694.
4. Y. Wei, J. Li, Z. Chen, F. Wang, W. Huang, Z. Hong*, J. Lin*. Multistage virtual screening and identification of novel HIV-1 protease inhibitors by integrating SVM, Shape, Pharmacophore and Docking methods. Eur. J. Med. Chem., 2015, 101, 409-418.
5. M. Yu, Z. Chen, W. Guo, J. Wang, Y. Feng, X. Kong, Z. Hong*. Specifically targeted delivery of protein to phagocytic macrophages. Int. J. Nanomed., 2015, 10, 1743-1757.
6. J. Wang, G. Fang,Y. He, D. Qu, M. Yu, Z. Hong, L. Liu.* Peptide O-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis. Angew. Chem. Int. Ed. 2015, 54(7), 2194-8.
联系方式：
电话 022-23498707
邮箱 hongzy@nankai.edu.cn
地址 天津市南开区卫津路94号南开大学生命科学学院生物站C-203室