研究贡献
恶性肿瘤是基因与环境交互作用引起的复杂疾病，系统揭示和阐明引起肿瘤的内因和外因，是实现肿瘤防治的重要基础。吴晨长期在科研一线从事肿瘤遗传学与肿瘤基因组学研究。通过开展中国最大的食管癌防治队列研究，建立食管癌基因组动态样本库和大数据库，构建癌变及进展风险预测模型，深入挖掘肿瘤基因组动态演进的分子机制，整合中国人群高发鳞癌及消化道恶性肿瘤多组学研究，推动中国人群食管癌的精准防治。
主要研究内容聚焦于：（1）运用全基因组关联研究策略，揭示食管癌、胃癌、胰腺癌、肺癌等恶性肿瘤易感基因或致病基因，为肿瘤的风险评估、早期检测和寻找防治措施提供依据；（2）通过多组学整合分析，构建食管癌易感基因和驱动基因全景，同时揭示酒精代谢基因变异与饮酒交互作用是食管癌重要病因；（3）深入挖掘组学数据并进行系统的功能基因组学筛查，通过细胞生物学和分子生物学等技术，阐明关联研究发现的易感基因及其变异的生物学功能, 为肿瘤个体化和精准医疗以及寻找药物靶点提供基础；（4）不同人群的遗传背景存在显著的差异，通过与多国家科学家紧密合作，绘制了不同人群、不同肿瘤的遗传图谱，为研究不同地区人群肿瘤发病风险差异原因提供了重要线索，不仅推进了对肿瘤遗传学的认识，而且极大提高了中国遗传学在国际的地位和影响力，在全基因组关联研究领域中起到引领作用。
2016 年以来主要代表性文章
1. Chu J, Niu X, Chang J,Shao M, Peng L, Xi Y, Lin A, Wang C, Cui Q, Luo Y, Fan W, Chen Y, Sun Y, Guo W,Tan W, Lin D, Wu C (2020). Metabolic remodeling by TIGARoverexpression is a therapeutic target in esophageal squamous-cell carcinoma.Theranostics, 10(8), 3488-3502. (co-corresponding author)
2. Chang J, Tian J, Zhu Y, Zhong R, Zhai K, LiJ, Ke J, Han QQ, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Yang Y, Zou D,Peng X, Zhang Z, Zhang X, Huang K, Yang M, Wang L, Wu C, Lin D, Miao X. Exome-wideanalysis identifies three low-frequency missense variants associated withpancreatic cancer risk in chinese populations. Nat Commun 2018;9(1) 3688. (co-corresponding author)
3. PengL, Cheng S, Lin Y, Cui Q, Luo Y, Chu J, Shao M, Fan W, Chen Y, Lin A, Xi Y, SunY, Zhang L, Zhang C, Tan W, Gao G, Wu C, Lin D (2018). CCGD-ESCC: A Comprehensive Databasefor Genetic Variants Associated with Esophageal Squamous Cell Carcinoma inChinese Population. Genomics ProteomicsBioinformatics 16(4):262-268. (co-corresponding author)
4. Chang J, Tian J, Zhu Y, Zhong R, Zhai K, Li J, Ke J,Han Q, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Yang Y, Zou D, Peng X,Zhang Z, Zhang X, Huang K, Yang M, Wang L, Wu C, Lin D, Miao X (2018).Exome-wide analysis identifies threelow-frequency missense variants associated with pancreatic cancer risk inChinese populations. Nat Commun 9(1):3688.(corresponding author)
5. HuangX, Zheng J, Li J, Che X, Tan W, Tan W, Shao M, Cheng X, Du Z, Zhao Y, Wang C, Wu C, Lin D (2018). Functional role of BTB and CNC Homology 1 gene in pancreatic cancer andits association with survival in patients treated with gemcitabine. Theranostics:3366-3379. (corresponding author)
6. Li J,Tan W, Peng L, Zhang J, Huang X, Cui Q, Zheng J, Tan W, Wu C, Lin D (2018). Integrativeanalysis of gene expression profiles reveals specific signaling pathwaysassociated with pancreatic duct adenocarcinoma. Cancer Commun (Lond)38(1):13. (corresponding author)
7. Chang J, Zhong R, Tian J,Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, YangY, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C, Miao X, Lin D (2018). Exome-wideanalyses identify low-frequency variant in CYP26B1 and additional codingvariants associated with esophageal squamous cell carcinoma. NatGenet 50(3):338-343. (co-corresponding author)
8. Qionghua Cui, Linna Peng, Lixuan Wei, Jiang Chang, Wenle Tan,Yingying Luo, Xudong Huang,Yanjie Zhao, Li J, Chu J, Shao M, Zhang C, Li C, Tan W, Lin D, Wu C (2018). Genetic variant repressing ADH1A expressionconfers susceptibility to esophageal squamous-cell carcinoma. Cancer Lett 421:43-50. (corresponding author)
9. Wei L,Shao M, Zhao Y, Zheng J, Chu J, Chang J, Cheng X, Qionghua C, Peng L, Luo Y,Tan W, Tan W, Lin D, Wu C (2018). Functional role of PLCE1 intronic insertionvariant associated with susceptibility to esophageal squamous-cell carcinoma.Carcinogenesis 39(2):191-201. (corresponding author)
10. Zhao Y, Wei L, Shao M, Huang X, Chang J, Zheng J, Chu J,Cui Q, Peng L, Luo Y, Tan W, Tan W, Lin D, WuC (2017). BRCA1-Associated ProteinIncreases Invasiveness of Esophageal Squamous Cell Carcinoma. Gastroenterology 153:1304-1319. (co-corresponding author)
11. Chang J, Tan W, Ling Z, Xi R, Shao M, Chen M, Luo Y, ZhaoY, Liu Y, Huang X, Xia Y, Hu J, Parker JS, Marron D, Cui Q, Peng L, Chu J, LiH, Du Z, Han Y, Tan W, Liu Z, Zhan Q, Li Y, Mao W, Wu C, Lin D (2017). Genomicanalysis of oesophageal squamous-cell carcinoma identifies alcoholdrinking-related mutation signature and genomic alterations. Nat Commun 8:15290. (co-correspondingauthor)
12. Cheng X, Wei L, Huang X, Zheng J, Shao M, Feng T, Li J,Han Y, Tan W, Tan W, Lin D, Wu C(2017). Solute Carrier Family 39 Member 6Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by IncreasingIntracellular Levels of Zinc, Activating Phosphatidylinositol 3-KinaseSignaling, and Up-regulating Genes That Regulate Metastasis. Gastroenterology 152:1985-1997.e12.(co-corresponding author)
13. Pan W, Zhou L,Ge M, Zhang B, Yang X, Xiong X, Fu G, Zhang J, Nie X, Li H, Tang X, Wei J, ShaoM, Zheng J, Yuan Q, Tan W, Wu C,Yang M, Lin D (2016). Whole exome sequencing identifies lncRNA GAS8-AS1 andLPAR4 as novel papillary thyroid carcinoma driver alternations. Hum Mol Genet 25:1875-1884. (co-corresponding author)
14. ZhengJ, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y,Miao X, Jiang G, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y,Zheng X, Shen H, Wu C, Lin D (2016).Pancreatic cancer risk variant in LINC00673 creates amiR-1231 binding site and interferes with PTPN11 degradation. Nat Genet 7:11843. (co-correspondingauthor)