副教授
教育背景博士（北京协和医科大学）硕士/学士（南京大学）
研究领域 NAD信号和疾病电子邮件 zhaoyongjuan@cuhk.edu.cn 个人简介赵教授于2001、2004和2007年分别从南京大学和协和医科大学获得学士、硕士和博士学位，在香港大学生理系完成博士后训练后，于2014年加入北京大学深圳研究生院担任副研究员，于2020年10月加入香港中文大学（深圳），现在医学院及切哈诺沃精准和再生医学研究院担任副教授。
赵博士一直从事源于NAD的钙信使cADPR等的生物合成和功能，开发相关工具，靶向NAD代谢/信号针对肿瘤和神经退行性疾病进行精准医疗探索。作为第一/二发明人申请7项中国专利，已获批两项；主持国家自然科学基金3项，深圳市或广东省项目6项；发表SCI学术论文40余篇；多次国际会议邀请报告；为多个学术期刊（包括Neurosientists、Cell Reports、Autophagy等）担任同行评议。
学术著作主要论文
Google Scholar Profile (Citation: 1393 till Feb 15, 2023; H-index: 21):
https://scholar.google.com/citations?user=V3x9K3wAAAAJ&hl=zh-TW
2023
Huang K#, Zhu WJ#, Li WH#, Lee HC*, Zhao YJ*, Lee C-S. Base-Exchange Enabling the Visualization of SARM1 Activities in Sciatic Nerve-Injured Mice. ACS Sens. 2023 Jan 23. doi: 10.1021/acssensors.2c02317.
2022
Hou YN#, Cai Y#, Li WH#, He WM, Zhao ZY, Zhu WJ, Wang Q, Liu J, Lee HC, Goran S*, Zhang HM*, Zhao YJ*. A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1. Nat Commun. 2022 Dec 22;13(1):7898.Lee HC, Deng QW, Zhao YJ*. The Calcium Signaling Enzyme CD38 - A Paradigm for Membrane Topology Defining Distinct Protein Functions. Cell Calcium. 2022; 101: 102514
2021
Li WH, Huang K, Cai Y, Wang QW, Zhu WJ, Hou YN, Wang S, Cao S, Zhao ZY, Xie XJ, Du Y, Lee C-S*, Lee HC*, Zhang H*, Zhao YJ*. Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate. Elife. 2021;10:e67381. Zhao YJ#,*, He WM#, Zhao ZY#, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. Acidic pH irreversibly activates the signaling enzyme SARM1. FEBS J. 2021 Dec;288(23):6783-6794.Wang C, Chen Y, Hou YN, Liu Q, Zhang D, Zhao H, Zhang Y, An S, Li L, Hou J, Huang G, Liu J, Zhao YJ*, Wei W*. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Feb 5. doi: 10.1007/s00259-021-05218-1.Chen YJ*, Deng QW*, Wang L, Guo XC, Yang JY, Li T, Xu Z, Lee HC, Zhao YJ. GALA peptide improves the potency of nanobody-drug conjugates by lipid-induced helix formation. Chem Commun (Camb). 2021 Feb 15;57(12):1434-1437Fu Z, Huang B, Tang J, Liu S, Liu M, Ye Y, Liu Z, Xiong Y, Zhu W, Cao D, Li J, Niu X, Zhou H, Zhao YJ, Zhang G, Huang H. The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Nat Commun. 2021 Jan 20;12(1):488.
2019
Zhao ZY, Xie XJ, Li WH, Liu J, Chen Z, Zhang B, Li T, Li SL, Lu JG, Zhang L, Zhang L-h, Xu Z, Lee HC*, Zhao YJ*. A cell-permeant mimetic of NMN activates SARM1 to produce cyclic ADP-ribose and induce non-apoptotic cell death. iScience, 2019; 15:452-466.Deng QW, Zhang J, Li T, He WM, Fang L, Lee HC*, Zhao YJ*. Identification of CD71 as a regulator of type II CD38 reveals tight topological compartmentation of intracellular cADPR production. J Biol Chem. 2019;294(42):15293-15303Wu Y, Zhang J, Fang L, Lee HC*, Zhao YJ*. A cytosolic chaperone complex controls folding and degradation of type III CD38. J Biol Chem. 2019 Mar 15;294(11):4247-4258Yang L$, Li T$, Li SL, Wu Y, Shi X, Jin H, Liu Z, Zhao YJ*, Zhang L*. Rational Design of Allosteric Inhibitors of CD38 and Synthesis of Intracellular Cyclic ADP-ribose. ChemBioChem. 2019 Oct 1;20(19):2485-2493.Lee HC, Zhao YJ. Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP. J Biol Chem. 2019 Dec 27;294(52):19831-19843.
2018
Fang C, Li T, Li Y, Xu GJ, Deng QW, Chen YJ, Hou YN, Lee HC*, Zhao YJ*. CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome. J Biol Chem. 2018 May 25;293(21):8151-8160.An N*, Hou YN*, Zhang QX, Li T, Zhang QL, Fang C, Chen H, Lee HC, Zhao Y&, Du X&. Anti-Multiple Myeloma Activity of Nanobody-Based Anti-CD38 Chimeric Antigen Receptor T Cells. Mol Pharm. 2018 Oct 1;15(10):4577-4588 Li T, Li SL, Fang C, Hou YN, Zhang Q, Du X, Lee HC*, Zhao YJ*. Nanobody-based dual epitopes protein identification (DepID) assay for measuring soluble CD38 in plasma of multiple myeloma patients. Anal Chim Acta. 2018 Oct 31;1029:65-71Jiang Y, Deng Q, Zhao H, Xie M, Chen L, Yin F, Qin X, Zheng W, Zhao Y*, Li Z*. Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α. ACS Chem Biol. 2018 Mar 16;13(3):628-635.
2017
Liu J*, Zhao YJ*&, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC&. Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Proc Natl Acad Sci U S A. 2017, 114(31):8283–8288.
Before 2017
Li T, Qi S, Unger M, Hou YN, Deng QW, Liu J, Lam MC, Wang XW, Du X, Zhang P, Koch-Nolte F, Hao Q, Zhang HM*, Lee HC*, Zhao YJ*. Immuno-targeting the multifunctional CD38 using nanobody. Sci Rep. 2016 Jun 2;6:27055.Zhao YJ*, Zhu WJ, Wang XW, Zhang LH, Lee HC*. Determinants of the membrane orientation of a calcium signaling enzyme CD38. BBA-Mol Cell Research. 2015 Sep;1853(9):2095-103. Zhao YJ*, Lam CM*, Lee HC. The membrane-bound enzyme CD38 exists in two opposing orientations. Sci Signal. 2012; 5(241):ra67. Zhao YJ, Zhang HM, Lam CM, Hao Q, Lee HC. Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic adp-ribose. J Biol Chem. 2011; 286(25):22170-7.Zhao YJ, Liu YX, Zheng DX. Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77. FEBS J. 2008; 275: 1025–1038.